Immunohistochemical expression

This commercially available antibody is directed against a protein of the endoplasmic reticulum.  It is a sensitive marker for plasma cells.  Positive staining is seen in plasma cell, plasmablasts, lymphoplasmacytoid cells, and B-immunoblasts.  However, positivity has been reported in other tumours, including melanocytic lesions, neuroendocrine tumours and many epithelial tumours.

Diagnostic utility


Adv Anat Pathol 1997;4:332.

Turley H, Jones M, Eerber W, Mayne K, de Waele M, Gatter K.   VS38: a new monoclonal antibody for detecting plasma cell differentiation in routine sections. J Clin Pathol 1994:47;418-22.

Banerjee SS, Shanks JH, Hasleton PS. VS38 immunostaining in neuroendocrine tumours. Histopathology 1997;230:256-9.

Shanks JH, Banerjee SS. VS38 immunostaining in melanocytic lesions. J Clin Pathol 1996:49;205-7.


©SMUHT/PW Bishop