CD101

The available monoclonal antibodies (BA27 and BB27) are only immunoreactive in frozen sections.

Immunohistochemical expression

• Dendritic cells of skin and peripheral lymphoid tissue.

• Activated T cells.

Diagnostic utility

• Identification of Langerhans' cell in Langerhans' cell histiocytosis. In some cases CD1a is more strongly expressed than CD101; in other cases the converse. This paper by Bouloc reports 11 cases, all in infants, at various anatomical sites.

References

Bouloc A et al. CD101 expression by Langerhans cell histiocytosis cells. Histopathology 2000;36:229-232.

©SMUHT/PW Bishop