CD205, DEC205

CD205 is a 205 kD protein expressed on the cell surface. It is a member of the family of C-type multilectins. It is thought to be involved in the endocytosis of glycoprotein antigens. Within the thymus, it has been implicated in the binding of apoptotic thymocytes as part of the thymocyte selection process.

Immunohistochemical expression

Thymic cortical epithelial cells and less intensely in medullary epithelial cells.
Dendritic cells: dermal dendrocytes, Langerhans cells, dendritic cells of lymph nodes and spleen.

	Skin	squamous cell carcinoma	9/711
	Skin	basal cell carcinoma	0/291
	Lung	adenocarcinoma	1/201
		squamous cell carcinoma	2/521
		large cell carcinoma	0/31
	Multiple other sites	squamous cell carcinoma	16/981
	Multiple other sites	adenocarcinoma	0/291

Thymic tumours, benign and malignant: staining is coarsely granular with cytoplasmic accentuation

Diagnostic utility

Diagnosis of thymoma

References

1 Nonaka D, Henley JD, Chiriboga L, et al. Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. Am J Surg Pathol 2007; 31:1038-44

This page last revised 11.11.2007.

©SMUHT/PW Bishop