CD10 in hairy cell leukaemia

Hairy cell leukemia (HCL) in Western patients typically lacks expression of CD5 and CD10. The immunophenotype is in contrast to Japanese HCL which typically expresses CD5 and CD10.

However, CD5 and CD10 positivity has ocassionally been reported in non-Japanese HCL1,2. There is one report of CD5+ cells in the bone marrow but a predominance of CD5- circulating cells3.

1Dunphy, C. H. Oza, Y. V. Skelly, M. E An otherwise typical case of non-Japanese hairy cell leukemia with CD10 and CDw75 expression: response to cladaribine phosphate therapy. J Clin Lab Anal 1999;13:141-4.

2Kaufmann, O. Flath, B. Spath-Schwalbe, E. Possinger, K. Dietel, M. Immunohistochemical detection of CD10 with monoclonal antibody 56C6 on paraffin sections. Am J Clin Pathol 1999;111:117-22

3Usha, L., Bradlow, B., Stock, W. and Platanias, L.C. CD5+ immunophenotype in the bone marrow but not in the peripheral blood in a patient with hairy cell leukemia. Acta Haematol 2000;103:210-3.