CD21 is the C3d complement receptor. Antibodies are effective on paraffin-embedded tissue1.

Immunohistochemical expression

CD35 shows similar staining of FDCs.

Diagnostic utility

Demonstration of the follicular dendritic cell meshwork of follicles in:


1 Leong A S-Y, Cooper K and Leong FJ W-M. Manual of diagnostic antibodies for immunohistology. 2nd edition, 2003

2 Sattar HA, Husain AN, Kim AY, et al. The presence of a CD21+ follicular dendritic cell network distinguishes invasive Quilty lesions from cardiac acute cellular rejection. Am J Surg Pathol 2006; 30:1008-13

This page last revised 19.9.2006.

©SMUHT/PW Bishop