CD 95, Fas cell surface receptor

The Fas receptor binds ther FAs ligand. The binding of the ligand triggers the Fas-associated death domain (FADD) protein, along with capase 8 and 10, culminating in cell apoptosis. Germline mutaion of CD95 gives rise to the autoimmune lymphoporliferative syndrome.

Immunohistochemical expression

Diagnostic utility

References

1 Mullauer L, Emhofer J, Wohlfart S, et al. Autoimmune lymphoproliferative syndrome (ALPS) caused by Fas (CD95) mutation mimicking sarcoidosis. Am J Surg Pathol 2008; 32:329-34

This page last revised 30.3.2008.

©SMUHT/PW Bishop