Calcitonin

Some antibodies produce non-specific staining; monoclonal antibodies are generally more specific.

Immunohistochemical expression

• C-cells of the thyroid

• medullary carcinomas of the thyroid

• follicular-parafollicular carcinoma of the thyroid

• some neuroendocrine carcinomas of the larynx1

References

1Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd edition. Churchill Livingstone. Page 962.

Copp DH, Cameron EC, Cheney BA, et al. Evidence for calcitonin--a new hormone from the parathyroid that lowers blood calcium. Endocrinology 1962; 70:638-49

Coombes RC, Hillyard C, Greenberg PB, et al. Plasma-immunoreactive-calcitonin in patients with non-thyroid tumours. Lancet 1974; 1:1080-3

Dayal Y, Tashjian AH, Jr.,Wolfe HJ. Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma. Cancer 1979; 43:1331-8

DeLellis RA, Rule AH, Spiler I, et al. Calcitonin and carcinoembryonic antigen as tumor markers in medullary thyroid carcinoma. Am J Clin Pathol 1978; 70:587-94

This page last revised 12.6.2001.

©SMUHT/PW Bishop