Caspase-3 is a member of the caspase family, which mediates the proteolytic cascades responsible for apoptosis.

Immunohistochemical expression


reactive follicular hyperplasia

germinal centres positive1


Classical Hodgkin lymphoma

43/46: expression by more than 10% of cells correlates with better survival1

Nodular lymphocyte predominance Hodgkin disease




Diagnostic utility



1Kandil M, Assad N, Amer K, El Naggar A. Caspase-3 expression in Hodkin's lymphoma. Pathological Society, January 2005, abstract 68.

This page last revised 27.12.2004.

©SMUHT/PW Bishop