Dedifferentiated liposarcoma with myosarcomatous component

Histopathology

The heterologous element in dedifferentiated liposarcoma with myosarcomatous component may be rhabdomyosarcomatous or leiomyosarcomatous. A rhabdomyosarcomatous component may be pleomorphic, spindle cell or round cell. Spindle cells may show cross striations.

Immunohistochemistry

 

 

with rhabdomyosarcomatous component

with leiomyosarcomatous component

pure leiomyosarcoma for comparison

  

MDM2

20/201

7/71

0/351

CDK4

20/201

7/71

0/351

SMA

5/201

7/71

35/351

h-Caldesmon

0/201

7/71

35/351

Desmin

20/201

5/71

33/351

Myogenin

20/201

0/71

0/341

CD117

0/191

0/71

0/351

Progesterone receptor

0/111

0/71

2/191

Differential diagnosis

Prognosis

Local recurrence is common. Metastases rare compared with other high grade sarcomas.

References

1 Binh MB, Guillou L, Hostein I, et al. Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. Am J Surg Pathol 2007; 31:1557-66

 

This page last revised 15.2.2008

©SMUHT/PW Bishop