Diffuse large B-cell lymphoma (DLBCL) of the lung


A diffuse large B-cell lymphoma that is localised to the lung at the time of presentation.


DLBCL constitutes 5-20% of primary pulmonary lymphomas. Most patients are older adults.

Clinical features

DLBCL may occur in association with collagen vascular disease, fibrosing alveolitis2, immunosuppressed transplant patients, in association with AIDS or other immunodeficiency states. Patients present with cough, haemoptysis, dyspnea or systemic "B" symptoms.


Masses are solid and usually multiple.

Macroscopic appearances


As for DLBCL at other sites. Some cases show areas of low-grade MALT lymphoma1.


As for DLBCL at other sites.

Differential diagnosis




Five year survival is up to 60%.


0 Tumours of the Lung, Pleura, Thymus and Heart. WHO Classification of Tumours. IARC Press 2004.

1 Fiche M, Caprons F, Berger F, et al. Primary pulmonary non-Hodgkin's lymphomas. Histopathology 1995; 26:529-37

2 Nicholson AG, Wotherspoon AC, Jones AL, et al. Pulmonary B-cell non-Hodgkin's lymphoma associated with autoimmune disorders: a clinicopathological review of six cases. Eur Respir J 1996; 9:2022-5

This page last revised 21.6.2005.

©SMUHT/PW Bishop