ES1

ES1

TTF-1

negative

weak

moderate or strong staining

<10% of cells

10%-50% of cells

>50% of cells

Normal tissues

lung

56/56

other

46/47(3 prostate, 4 kidney, 2 endometrium, 3 ovary, 5 thyroid, 6 urinary bladder, 2 oesophagus, 5 mesothelium, 8 colonic mucosa, 4 pancreas, 5 gastric mucosa)

1/47(focal positivity of a few normal breast acini adjacent to a ductal carcinoma)

Lung tumours

Adenocarcinoma

3/22(well-differentiated non-mucinous adenocarcinomas)

11/22

8/22

20/22

Undifferentiated non small cell carcinoma

1/6(an undifferentiated large cell carcinoma with some squamous features)

3/6

2/6

1/6

Bronchoalveolar carcinoma

4/7

3/7

6/7

Adenosquamous carcinoma

1/2(staining restricted to glandular component)

1/2(staining restricted to glandular component)

0/2

Squamous cell carcinoma

3/5

2/5

0/5

Small cell carcinoma

3/3

0/3

Atypical adenomatous hyperplasia

2/6

3/6

1/6

0/6

Extra-pulmonary mucin-secreting tumours

Carcinoid tumour

3/3

0/3

Colonic adenocarcinoma

1/15

3/15

3/15

5/15

3/15

0/15

Breast ductal carcinoma

2/8

1/8

3/8

2/8

0/8

Pancreatic adenocarcinoma

1/6

2/6

1/6

2/6

0/6

Gastric adenocarcinoma

2/6

1/6

2/6

1/6

0/6

Gallbladder adenocarcinoma

1/1

0/1

Oesophageal adenocarcinoma

1/3

2/3

0/3

Urinary bladder adenocarcinoma

1/2

1/2

0/2

Ovarian mucinous adenocarcinoma

2/3

1/3

0/3

Tracheal adenoid cystic carcinoma

1/1

0/1

Urothelial carcinoma

2/4

1/4

1/4

0/4

Colonic adenoma

1/4

2/4

1/4

0/4

Extra-pulmonary non-mucinous tumours

Renal cell carcinoma

3/4

1/4

0/4

Hepatocellular carcinoma

2/5

3/5

0/5

Ovarian serous papillary carcinoma

4/4

0/4

Papillary thyroid carcinoma

4/5

1/5

0/5

Salivary pleomorphic adenoma

3/3

0/3

Mesothelioma

5/5

0/5

Prostatic adenocarcinoma

3/3

0/3

Endometrioid carcinoma

2/2

0/2

Oesophageal squamous carcinoma

1/1

0/1