Endometrioid carcinomas are associated with hormone replacement therapy and endometrial hyperplasia; they express ER and PR. Clear cell and serous endometrial carcinomas tend to occur in older women against a background of endometrial atrophy and are unassociated with hormone replacement therapy. Some clear cell carcinomas show the architectural and cytological appearances of serous carcinoma. Serous carcinomas over-express p53.
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Staining category |
I
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II
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III |
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