Focal uterine serous carcinoma and endometrial intraepithelial carcinoma

Uterine serous carcinoma and intra-endometrial carcinoma may occur focally within endometrial polyps or non-polypoidal endometrium in the elderly. There is usually a sharp transition from atrophic to severely atypical epithelium. The appearances of serous carcinoma may be mimicked by reactive atypia and oxyphil metaplasia.

	non-neoplastic / metaplastic epithelium	focal serous carcinoma / intraepithelial carcinoma
oestrogen receptor	positive	negative
p53	negative	positive
MIB1 proliferation index	low	high

References

1McCluggage, W. G. (2004). "A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms." Adv Anat Pathol 11(3): 162-71.

2Silva, E. G. and R. Jenkins (1990). "Serous carcinoma in endometrial polyps." Mod Pathol 3(2): 120-8.

3Ambros, R. A., M. E. Sherman, et al. (1995). "Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation." Hum Pathol 26(11): 1260-7.

This page last revised 29.5.2004.