Giant lamellar bodies are pulmonary inclusions. They have most often bee described in association with sclerosing haemangioma but are also seen with low grade lymphoma of the lung including marginal zone lymphoma1. They are reported not to occur with reactive lymphoid infiltrates or high grade lymphomas1.
Ultrastructural examination has shown concentrically arranged extracellular material forming roughly spherical structures up to 25 microns in diameter. The GLBs were often surrounded by foamy cells and cholesterol clefts, supporting an origin, at least in part, from products of cell breakdown and surfactant degradation. They stain for surfactant apoprotein A but not for surfactant apoprotein B.
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