Granulosa cell tumour of testis, adult type

Epidemiology

This is a very rare tumour.

Clinical features

20% of cases are associated with gynaecomastia.

Histopathology

The architecture shows the same patterns as seen in the ovary. Nuclear grooving is of variable prominence.

Immunohistochemistry

Differential diagnosis

• sex cord-stromal tumour, unclassified; may contain focal granulosa tumour-like areas, but is not pure.

• Leydig cell tumour; may show nuclear grooving.

Prognosis

About 20% of tumours are reported as showing malignant behaviour.

References

1Shanks JH, Iczkowski KA. Non-germ cell tumours of the testis. Current Diagnostic Pathology 2002;8:83-93.

2Jimenez-Quintero, L. P., Ro, J. Y., Zavala-Pompa, A., Amin, M. B., Tetu, B., Ordonez, N. G., Ayala, A. G. Granulosa cell tumor of the adult testis: a clinicopathologic study of seven cases and a review of the literature. Hum Pathol 1993;24:1120-5.

3Due, W., Dieckmann, K. P., Niedobitek, G., Bornhoft, G., Loy, V., Stein, H. Testicular sex cord stromal tumour with granulosa cell differentiation: detection of steroid hormone receptors as a possible basis for tumour development and therapeutic management. J Clin Pathol 1990;43:732-7.

This page last revised 2.12.2002.

©SMUHT/PW Bishop