The IgH/CCND1 is created by a t(11;14)(q13;q32) translocation, leading to the aberrant expression of cyclin D1. It is is present in most cases of mantle cell lymphoma1.

The translocation also occurs in 15%-20% of cases of myeloma as detected by FISH, it is associated with upregulation of cyclin D1. It is likely to be associated with a serum monoclonal paraprotein of less than 10g/l, a lymphoplasmacytic morphology and a lower plasma cell labelling index. The reported prognosis in such patients has been variable, with one large study showing a better response to treatment and better survival2.

Other lymphomas including follicular lymphoma and marginal zone lymphoma are usually negative1.

Diagnostic utility


1 Frater JL, Tsiftsakis EK, Hsi ED, et al. Use of novel t(11;14) and t(14;18) dual-fusion fluorescence in situ hybridization probes in the differential diagnosis of lymphomas of small lymphocytes. Diagn Mol Pathol 2001; 10:214-22

2 Fonseca R, Blood EA, Oken MM, et al. Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood 2002; 99:3735-41 FULL TEXT

3 Schlette E, Bueso-Ramos C, Giles F, et al. Mature B-cell leukemias with more than 55% prolymphocytes. A heterogeneous group that includes an unusual variant of mantle cell lymphoma. Am J Clin Pathol 2001; 115:571-81


This page last revised 17.11.2006.

©SMUHT/PW Bishop