Insulin-like growth factor II mRNA binding protein 3, IMP3, L523S, KOC (K-homologous domain-containing protein over-expressed in cancer, IGF2BP3)

epithelium

stroma

Endometrium

atrophic

1/18(one case showed moderate staining of <25% of tissue)1

0/181

weakly proliferative

1/15(one case showed moderate staining of <25% of tissue)1

0/151

proliferative

1/16(one case showed weak staining of <25% of tissue)1

0/161

secretory

0/191

5/19(five cases showed staining of 25%-49% of tissue)1

menstrual

0/81

4/8(four cases showed staining of <25%% of tissue)1

benign, NOS

0/203

atypical endometrial hyperplasia/intra-epithelial neoplasia

3/35(two cases showed staining of 25%-49% of tissue, one case showed staining of <25% of tissue)1

serous glandular dysplasia

6/21(two cases showed staining of 80%-100% of tissue, one case showed staining of 50%-79%% of tissue, three cases showed staining of 25%-49% of tissue)1

serous intra-epithelial neoplasia

16/18(twelve cases showed staining of 80%-100% of tissue, four cases showed staining of 50%-79%% of tissue, two cases showed staining of 25%-49% of tissue)1

clear cell glandular dysplasia

2/12(one case showed staining of 80%-100% of tissue, one case showed staining of 50%-79%% of tissue)1

clear cell intra-epithelial neoplasia

6/8(three cases showed staining of 80%-100% of tissue, two cases showed staining of 50%-79%% of tissue, one case showed staining of 25%-49% of tissue)1

gestational endometrium

0/161

16/16(decidua: seven cases showed staining of 80%-100% of tissue, six cases showed staining of 50%-79%% of tissue, three cases showed staining of 25%-49% of tissue. chorionic villi positive)1

trophoblast

16/16(all sixteen cases showed staining of 80%-100% of tissue)1

endometrial carcinoma

endometrioid

5/70(two cases showed staining of 50%-79%% of tissue, two cases showed staining of 25%-49% of tissue, one case showed staining of <25% of tissue)1, 68/122(8 cases staining of 50% of cells, 10 cases staining of 21-50% of cells, 20 cases staining of 6-20% of cells, 30 cases staining of 1-5% of cells; expression correlates with tumour grade)3

serous

50/51(forty five cases showed staining of 80%-100% of tissue, three cases showed staining of 50%-79%% of tissue, one case showed staining of 25%-49% of tissue, one case showed staining of <25% of tissue)1, 45/45(39 cases staining of 50% of cells, 3 cases staining of 21-50% of cells, 3 cases staining of 6-20% of cells)3

clear cell

11/18(seven cases showed staining of 80%-100% of tissue, two cases showed staining of 50%-79%% of tissue, two cases showed staining of 25%-49% of tissue, one case showed staining of <25% of tissue)1

mucinous

1/8(one case showed staining of <25% of tissue)1

other

7/15(three cases showed staining of 80%-100% of tissue, two cases showed staining of 50%-79%% of tissue, one cases showed staining of 25%-49% of tissue, one case showed staining of <25% of tissue)1

Stage

IMP3-negative

IMP3-positive

I

98%

44%

II

94%

41%

II

62%

16%