Large cell calcifying Sertoli cell tumour of the testis

Epidemiology

This is a rare tumour. The mean age at diagnosis is 21 years.

Clinical features

There is an association with Carney's syndrome, lentigines and myxomas.

Histopathology

Tumour cells are large with abundant eosinophilic granular cytoplasm (resembling Leydig cells). Calcification may be psammomatous, dystrophic-appearing to confluent with ossification. Calcification may be reduced/absent in metastases.

Immunohistochemistry

inhibin	positive1
cytokeratin	negative or focal1
S-100	positive1
EMA	negative1

Ultrastructure

Charcot-Böttcher filaments may be present.

Differential diagnosis

Leydig cell tumour: lacks calcification, may contain Reinke crystals.

Prognosis

175 of cases show malignant behaviour. Those associated with Carney's syndrome are usually benign.

References

1Shanks JH, Iczkowski KA. Non-germ cell tumours of the testis. Current Diagnostic Pathology 2002;8:83-93.

This page last revised 2.12.2002.