Maspin is a protein related to the Serine Protease Inhibitor family. It is thought to be a tumour suppressor gene, inhibiting tumour formation angiogenesis and metastases. p53 regulates the expression of maspin.

Immunohistochemical expression

The protein can be variously detected in both cytoplasm and nucleus.

Diagnostic utility


1Mohsin, S. K., M. Zhang, et al. (2003). "Maspin expression in invasive breast cancer: association with other prognostic factors." J Pathol 199(4): 432-5.

2Xia, W., Y. K. Lau, et al. (2000). "High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma." Oncogene 19(20): 2398-403.

3Maass, N., T. Hojo, et al. (2001). "Expression of the tumor suppressor gene Maspin in human pancreatic cancers." Clin Cancer Res 7(4): 812-7.


This page last revised 13.9.2004.

©SMUHT/PW Bishop