Primary mediastinal liposarcoma

Epidemiology

Primary liposarcoma represents less than 1% of all mediastinal tumours. They occur across a wide age range, but most patients are over 40 years old. There is no gender predominance.

Clinical features

Patients present with dyspnea or cough.

Histopathology

 

Well differentiated liposarcoma

adipocytic

5/241

  

spindle cell

2/241

  

mixed adipocytic and spindle cell

1/241

  

inflammatory

1/241

  

mixed adipocytic and sclerosing

1/241

  

total

10/241

  

Dedifferentiated liposarcoma

low grade

3/241

high grade

5/241

total

8/241

Pleomorphic liposarcoma

myxofibrosarcoma-like

2/241

total

4/241

Myxoid liposarcoma

2/241
     
     

Prognosis

Well differentiated liposarcoma has a good prognosis with most patients disease-free. Dedifferentiated liposarcoma and Pleomorphic liposarcoma may metastasis to lung or distal sites1.

References

1 Hahn HP,Fletcher CD. Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases. Am J Surg Pathol 2007; 31:1868-74

 

This page last revised 9.3.2008

©SMUHT/PW Bishop