Nuclear protein in testis, NUT

NUT is a gene on chromosome 15.   NUT midline carcinoma are aggressive tumours with translocations involving the NUT gene.

Immunohistochemical expression


  NUT midline carcinoma 26/301  
Dysgerminoma 7/111
Embryonal carcinoma 3/351
Endodermal sinus tumour 0/11
Germ cell tumour NOS 0/31
Seminoma 2/331
Struma ovarii 0/41
Teratoma, immature 0/91
Teratoma, mature 0/31
Yolk sac tumour 0/21
non-germ cell, non-NUT carcinoma 0/8891
Normal tissue 5/381


Diagnostic utility


1 Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, et al. Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol. 2009 Jul;33(7):984-91.

This page last revised 15.8.2009.

©SMUHT/PW Bishop