PTEN is a tumour suppressor gene mapping to chromosome 10q23. Germline mutations occur in Cowden disease. Somatic mutations occur in various carcinomas.

Immunohistochemical expression


Diagnostic utility


1Darvishian, F., A. J. Hummer, et al. (2004). "Serous endometrial cancers that mimic endometrioid adenocarcinomas: a clinicopathologic and immunohistochemical study of a group of problematic cases." Am J Surg Pathol 28(12): 1568-78.



This page last revised 4.1.2005.

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