Parvovirus B19

Parvovirus B19 produces a prolonged fatigue syndrome with pancytopenia and cervical lymphadenopathy. Lymph nodes show apoptotic sinus histiocytosis without necrosis.

Immunohistochemical expression

The antibody R92F6 recognises the structural proteins VP1 and VP2 of parvovirus B19. It stains single cells within lymph node sinuses.


1 Knosel T, Meisel H, Borgmann A, et al. Parvovirus B19 infection associated with unilateral cervical lymphadenopathy, apoptotic sinus histiocytosis, and prolonged fatigue. J Clin Pathol 2005; 58:872-5

This page last revised 15.11.2006.

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