Peripherin is a type III intermediate filament present is cells derived from the neural tube and neural crest.

Immunohistochemical expression

Diagnostic utility



1Prieto, V. G., N. S. McNutt, et al. (1997). "The intermediate filament peripherin is expressed in cutaneous melanocytic lesions." J Cutan Pathol 24(3): 145-50.

2Escurat, M., K. Djabali, et al. (1991). "Origin of the beta cells of the islets of Langerhans is further questioned by the expression of neuronal intermediate filament proteins, peripherin and NF-L, in the rat insulinoma RIN5F cell line." Dev Neurosci 13(6): 424-32.

3Baudoin, C., G. Meneguzzi, et al. (1993). "Peripherin, a neuronal intermediate protein, is stably expressed by neuroendocrine carcinomas of the skin, their xenograft on nude mice, and the corresponding primary cultures." Cancer Res 53(5): 1175-81.

4Pedersen, W. A., L. E. Becker, et al. (1993). "Expression and distribution of peripherin protein in human neuroblastoma cell lines." Int J Cancer 53(3): 463-70.

This page last revised 24.1.2004.

©SMUHT/PW Bishop