Prostate specific membrane antigen, PSMA

PSMA3 is a Mr 100,000 type II membrane protein consisting of 750 amino acids. Although PSMA exhibits in vitro neuropeptidase activity, its function in vivo has not been fully elucidated. The PSMA gene is located on chromosome 11.

Immunohistochemical expression

Normal tissues: renal tubules, prostatic epithelium, duodenal and colonic mucosa1.

	Prostatic carcinoma, primary	33/351
	Prostatic carcinoma, metastatic	15/261
	Renal cell carcinoma	0/171
	Transitional cell carcinoma	0/131
	Colonic carcinoma	0/191

Diagnostic utility

Diagnosis of prostatic carcinoma

References

1 Silver DA, Pellicer I, Fair WR, et al. Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 1997; 3:81-5

This page last revised 17.5.2008.

5SMUHT/PW Bishop