Pulmonary adenofibroma

Pulmonary adenofibromas have variously been interpreted as harmatomas2 or as pseudopapillary variants of solitary fibrous tumour1.

Clinical features

These are tumours of middle aged adults.

Macroscopic appearance

These are solitary peripheral "coin" lesions.

Histopathology

There are large pseudopapillae covered by bland cuboidal epithelium. The stroma is fibrous, containing bland spindle cells. There is a resemblance to adenofibroma of the female genital tract.

Immunohistochemistry

 

Epithelium

Stroma

EMA

positive0,1

negative0,1

cytokeratins

positive0,1

negative0,1

TTF-1

positive1

negative1

S-100

 

negative0,1

SMA

 

negative0,1

desmin

 

negative0,1

CD34

 

negative0, positive1

bcl-2

 

focal1

CD99

 

focal1

Calretinin

 

negative1

Differential diagnosis

Prognosis

Benign

References

0 Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd edition. Churchill Livingstone. Page 197.

1 Cavazza A, Rossi G, De Marco L, et al. [Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited]. Pathologica 2003; 95:162-6

2 Suster S,Moran CA Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. Histopathology 1993; 23:547-51

 

This page last revised 1.6.2001.