Pulmonary adenofibroma

Pulmonary adenofibromas have variously been interpreted as harmatomas2 or as pseudopapillary variants of solitary fibrous tumour1.

Clinical features

These are tumours of middle aged adults.

Macroscopic appearance

These are solitary peripheral "coin" lesions.

Histopathology

There are large pseudopapillae covered by bland cuboidal epithelium. The stroma is fibrous, containing bland spindle cells. There is a resemblance to adenofibroma of the female genital tract.

Immunohistochemistry

	Epithelium	Stroma
EMA	positive0,1	negative0,1
cytokeratins	positive0,1	negative0,1
TTF-1	positive1	negative1
S-100		negative0,1
SMA		negative0,1
desmin		negative0,1
CD34		negative0, positive1
bcl-2		focal1
CD99		focal1
Calretinin		negative1

Differential diagnosis

solitary fibrous tumour with entrapped glands: in adenofibroma the glands are more evenly distributed.
pulmonary blastoma

Prognosis

Benign

References

0 Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd edition. Churchill Livingstone. Page 197.

1 Cavazza A, Rossi G, De Marco L, et al. [Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited]. Pathologica 2003; 95:162-6

2 Suster S,Moran CA Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. Histopathology 1993; 23:547-51

This page last revised 1.6.2001.