RON proto-oncogene
The RON proto-oncogene is a tyrosine kinase receptor, the ligand for macrophage stimulating protein. This ligand stimulates proliferation and motility while inhibiting apoptosis. Over-expression has been demonstrated in a number of human tumours. A mutant auto-activating form of RON may confer high metastatic potential1.
Immunohistochemical expression
A study using Western blot analysis showed strong expression in renal oncocytomas but not in other renal tumours.
| |
|
negative
|
weak
|
moderate
|
strong
|
positive, NOS
|
|
| |
Oncocytoma
|
0/702
|
1/702
|
18/702,
3/12(granular [eosinophilic] variant, cytoplasmic and/or membrane staining)3
|
51/702,
9/12(granular [eosinophilic] variant, cytoplasmic and/or membrane staining)3
|
18/181
|
|
|
Chromophobe cell carcinoma
|
0/572
|
2/572
|
8/572,
5/11(cytoplasmic and/or membrane)3
|
47/572,
6/11(cytoplasmic and/or membrane)3
|
0/51
|
|
Clear cell carcinoma
|
19/632,
3/6(granular [eosinophilic] variant)3
|
40/632,
3/6(granular [eosinophilic] variant, cytoplasmic with or without membrane staining)3
|
3/632
|
1/632
|
0/191
|
|
Papillary cell carcinoma
|
0/382
|
24/382
|
14/382
|
0/382
|
0/71
|
|
Poor differentiated carcinoma with sarcomatoid areas
|
|
|
|
|
0/11
|
| |
|
|
|
|
|
Diagnostic utility
RON immunoreactivity is of NO value in differentiating renal oncocytoma from chromophobe cell carcinoma.
References
1Rampino, T., M. Gregorini, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma." Am J Surg Pathol 27(6): 779-85.
2Patton, K. T., M. S. Tretiakova, et al. (2004). "Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell Carcinoma." Am J Surg Pathol 28(8): 1045-50. (study used tissue microarrays)
3 Wang HY,Mills SE. KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. Am J Surg Pathol 2005; 29:640-6
This page last revised 17.7.2005.
©SMUHT/PW Bishop