Some authors find the staining capricious and unreliable2.
Positive in proximal rather than distal normal renal tubules and is seen along the brush border3,6.
|
primary renal cell carcinoma |
clear cell |
59/70(solid 56/62, cystic 3/8)1, 5/6 (granular [eosinophilic] variant: the negative case was Fuhrman grade IV)4, 279/363 (using clone PN-15: staining is membranous; 242 of the 279 cases showed strong staining)6, 234/355 (using clone 66.4C2: staining is membranous; 173 of the 234 cases showed strong staining)6 |
|
papillary |
56/58 (papillary adenoma 4/4, papillary carcinoma 52/54)1, 43/46 (using clone PN-15: staining is membranous; 40 of the 43 cases showed strong staining)6, 34/46 (using clone 66.4C2: staining is membranous; 32 of the 34 cases showed strong staining)6 |
|
|
chromophobe |
5/11 (typical variant 5/8, eosinophilic variant 0/3)1, 0/114, 0/22 (using either clone PN-15 or 66.4C2)6 |
|
|
sarcomatoid |
2/91 |
|
|
collecting duct |
0/51 |
|
|
overall |
122/153 (80%)1 |
|
|
metastatic renal cell carcinoma |
42/63 (67%)1, 76/149 (metastatic tumours; using clone PN-15: staining is membranous; 61 of the 76 cases showed strong staining)6 |
|
|
other primary renal tumours |
0/64 (oncocytoma 0/15, transitional cell carcinoma 0/20, mesoblastic nephroma 0/3, cystic nephoma 0/3, lymphoma 0/8, angiomyolipoma 0/3, mixed stromal and epithelial tumour 0/4, nephroblastoma 0/8)1 , 0/12(oncocytoma)4, 0/15 (oncocytoma; using either clone PN-15 or 66.4C2)6 |
|
|
non-renal primary tumours |
breast |
5/15 (2/10 invasive ductal carcinoma, 1/2 invasive lobular carcinoma , 0/3 mucinous carcinoma , 1/1 ductal papilloma , 1/1 phyllodes tumour)1 |