Renal mixed epithelial and stromal tumour

Definition

This is a rare tumour, most often occurring in women, a number of whom are receiving hormone replacement therapy. Similar tumours have probably been reported as "cystic hamartoma of the pelvis"3 and as "adult mesoblastic nephroma"2.

Macroscopic appearances

The tumour is often located in the renal pelvis. It forms a well-circumscribed mass with solid and cystic areas.

Histopathology

There is a mixture of bland spindle cells and epithelial elements tubular forming tubules and cysts.

Immunohistochemistry

 

 

Epithelial component

Spindle cell component

 

Cam5.2

10/101

0/101

AE1/AE3

10/101

0/101

SMA

0/101

10/101

Desmin

0/101

10/101

Vimentin

4/101

10/101

oestrogen receptor

3/101

7/101

progesterone receptor

0/101

3/101

CD34

0/101

0/101

S-100

0/101

0/101

HMB45

0/101

0/101

     

Differential diagnosis

Prognosis

The few cases reported have been benign.

References

1Adsay, N. V., J. N. Eble, et al. (2000). "Mixed epithelial and stromal tumor of the kidney." Am J Surg Pathol 24(7): 958-70.

2Nagao, T., I. Sugano, et al. (1999). "Cystic partially differentiated nephroblastoma in an adult: an immunohistochemical, lectin histochemical and ultrastructural study." Histopathology 35(1): 65-73.

3Pawade, J., G. N. Soosay, et al. (1993). "Cystic hamartoma of the renal pelvis." Am J Surg Pathol 17(11): 1169-75.

 

This page last revised 6.1.2004.

©SMUHT/PW Bishop