Sertoli-stromal cell tumour of the ovary

Epidemiology

Clinical features

This is a sex cord stroma-derived tumour of the ovary of young adults. These tumours are commonly virilising.

Histopathology

Tubular sex cord-like structures resemble the seminiferous tubules of the testis. There is a variable stromal component resembling Leydig cells.

Immunohistochemistry

	Sertoli cell component	Stromal component
a-inhibin	diffusely positive	focally positive
Cam5.2	diffusely positive	negative
Vimentin	diffusely positive	diffusely positive
Oestrogen receptor	equivocal	equivocal
Progesterone receptor	diffusely positive	focally positive
Androgen receptor	equivocal	equivocal

Ultrastructure

The tubules have a composite structure of Sertoli cells and rete cells.

Prognosis

Well differentiated tumours are considered benign. Intermediate and poorly differentiated tumours may show malignant behavior.

References

Kato, N., Fukase, M., Ono, I., Matsumoto, K., Okazaki, E., Motoyama, T. Sertoli-stromal cell tumor of the ovary: immunohistochemical, ultrastructural, and genetic studies. Hum Pathol 2001;32:796-802

This page last revised 10.11.2001.

©SMUHT/PW Bishop