Smad4, DPC4

Smad4 is a tumour suppressor gene located at 18q21.1. It is inactivated in 55% of pancreatic adenocarcinomas1 and in 34% of carcinomas of the Ampulla of Vater but not in the associated adenomas2.

Immunohistochemical expression


Diagnostic utility



1 Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271:350-3

2 McCarthy DM, Hruban RH, Argani P, et al. Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases. Mod Pathol 2003; 16:272-8


This page last revised 27.6.2005.

©SMUHT/PW Bishop