TFE3 is one of four members of the basic/helix-loop-helix/leucine zipper transcription factor subfamily MiT, the others being TFEB, TFEC and MITF.  

Immunohistochemical expression

Immunohistochemical positivity is seen in tumours with gene fusions involving the TFE3 transcription factor.

Diagnostic utility


1 Yamashita K, Fletcher CD. PEComa presenting in bone: clinicopathologic analysis of 6 cases and literature review. Am J Surg Pathol. 2010 ov;34(11):1622-9.

This page last revised 29.11.2010.

©SMUHT/PW Bishop