TLS/EWS-CHOP

Myxoid and round cell liposarcomas consistently show a t(12;22)(q13;q11-12) and t(12;22)(q13;q12) translocations. Monoclonal antibodies have been raised against the two resulting chimeric proteins, TLS-CHOP and EWS-CHOP. One of these monoclonal antibodies, anti-TLS/EWS-CHOP antibody (clone 14), holds promise for the identification of myxoid/round cell liposarcoma in formalin-fixed paraffin-embedded tissue. Staining is nuclear.

Immunohistochemical expression

		anti-TLS/EWS-CHOP clone 14
	Myxoid / round cell liposarcoma	21/231
	Well-differentiated liposarcoma	0/21
	Pleomorphic liposarcoma	0/21
	PNET	0/41
	MFH	0/81
	Leiomyosarcoma	0/21
	Embryonal rhabdomyosarcoma	0/11
	Monophasic synovial sarcoma	0/21
	MPNST	0/21

Diagnostic utility

Identification of myxoid / round cell liposarcoma: more cases need to be studied.

References

1 Oikawa K, Ishida T, Imamura T, et al. Generation of the novel monoclonal antibody against TLS/EWS-CHOP chimeric oncoproteins that is applicable to one of the most sensitive assays for myxoid and round cell liposarcomas. Am J Surg Pathol 2006; 30:351-6

This page last revised 13.4.2006.

©SMUHT/PW Bishop