Thymic large cell neuroendocrine carcinoma

Definition

A high-grade malignancy composed of large cells with neuroendocrine features.

Histopathology

The tumour commonly shows palisading, rosettes or a trabecular architecture. Necrosis is often extensive. There is a high mitotic rate.

Immunohistochemistry

Cytokeratin

1/12

EMA

1/12

Chromogranin

2/21, 0/12

Synaptophysin

1/11, 1/12

NSE

2/21

CD56

2/21

p53

1/12

bcl-2

0/12

CD5

1/12
   
   

References

J Rosai et al. Histological typing of tumours of the thymus. WHO International histological classification of tumours. Springer-Verlag, second edition, 1999.

1Tiffet, O., A. G. Nicholson, et al. (2003). "A clinicopathologic study of 12 neuroendocrine tumors arising in the thymus." Chest 124(1): 141-6.

2Histopathology 2004;44:367-374.

This page last revised 30.3.2004.

©SMUHT/PW Bishop