Typical immunohistochemical staining profile for Small Round Blue Cell Tumours of the sinonasal tract

  reference 1

Cytokeratin

Chromogranin

Synaptophysin

Neuron-Specific Enolase

HMB45

S-100

CD56

Desmin

CD99

EBER

  
Olfactory neuroblastoma

-

+

+

+

-

+

-

-

-

-
Nasal melanoma

-

-

-

+

+

+

-

-

-

-

Extranodal NK/T-cell lymphoma (nasal type)

-

-

-

-

-

-

+

-

-

+
Neuroendocrine carcinoma

+

+

+

+

-

+

-

-

-

-
SNUC

+

-

-

-

-

-

-

-

-

-
PNET

-

-

-

+/-

-

-

-

-

+

-
Nasopharyngeal carcinoma

+

-

-

-

-

-

-

-

-

+
Pituitary adenoma

+

+

+

+

-

-

-

-

-

-
Alveolar rhabdomyosarcoma

-

-

-

-

-

-

-

+

-

-
 

 

 

 

 

 

 

 

 

 

 
 

 

 

 

 

 

 

 

 

 

 

 

Detailed information for calretinin and p63:

    calretinin p63  
Olfactory neuroblastoma 20/211 0/211
Nasal melanoma 0/51 0/51

Diffuse large B-cell lymphoma

 1/41 4/51

Mantle cell lymphoma

 0/11 1/11

Extranodal NK/T-cell lymphoma (nasal type)

 0/41 1/41
Poorly differentiated neuroendocrine carcinoma 1/11 1/11
Moderately differentiated neuroendocrine carcinoma 0/11 0/11
Small cell neuroendocrine carcinoma 1/21 0/21
Non-keratinising squamous cell carcinoma 0/21 2/21
SNUC 0/61 1/61
High-grade sinonasal non-intestinal–type adenocarcinoma 0/11 0/11
Ewing sarcoma / PNET 0/61 2/61
Teratocarcinosarcoma 1/11 0/11
Pituitary adenoma 3/31 0/31
Alveolar rhabdomyosarcoma 0/41 0/41
     
     

 

References

1 Wooff JC, Weinreb I, Perez-Ordonez B, Magee JF, Bullock MJ. Calretinin staining facilitates differentiation of olfactory neuroblastoma from other small round blue cell tumors in the sinonasal tract. Am J Surg Pathol. 2011 Dec;35(12):1786-93.

This page last revised 7.3.2012

©SMUHT/PW Bishop