Only staining of the brush border appears to be of diagnostic value.
|
staining of the brush border more than 25% of tumour cells |
|
Adenocarcinomas |
Colorectum |
60/731, 24/242 |
Oesophagus |
7/91 |
|
Stomach |
10/241, 6/62 |
|
Duodenum |
4/41 |
|
Pancreas |
8/221, 12/142 |
|
Gallbladder / cholangiocarcinoma |
9/161, 2/22 |
|
Hepatocellular |
0/121, 1/12 |
|
Ovary, mucinous adenocarcinoma |
9/141 |
|
Ovary, non-mucinous, NOS |
0/311 |
|
Breast |
0/341, 0/122 |
|
Endometrium |
4/112 |
|
Ovary |
0/92 |
|
Prostate |
0/241 |
|
Bladder adenocarcinoma |
3/31 |
|
Kidney |
0/71, 13/212 |
|
Thyroid |
0/361 |
|
Adenoma |
Duodenum |
10/101 |
Ovary, mucinous cystadenoma |
0/131 |
|
Ovary, mucinous borderline tumour |
0/41 |
|
Gastrointestinal carcinoid |
4/121 |
|
Lung primaries |
Squamous cell carcinoma |
0/111 |
Adenocarcinoma NOS |
||
0/21, 1/143 |
||
non-small cell and NOS |
3/331 |
|
Small cell carcinoma |
0/41 |
|
Mesothelioma |
0/71, 0/72 |
|
Other carcinomas |
transitional cell carcinoma of bladder |
3/211 |
salivary gland pleomorphic adenoma |
0/61 |
|
salivary gland low grade carcinoma |
0/61 |
|
head and neck squamous cell carcinoma |
0/131 |
|
Villin appears to be inferior to CDX2 in sensitivity and specificity for the identification of metastases from colorectal and other gastrointestinal primaries. However, it may be useful in combination with CDX2, particularly in extra-gastrointestinal mucinous tumours with anomalous positivity for CDX-2.
References
This page last revised 21.5.2004.
©SMUHT/PW Bishop