c-erbB-2 in thyroid tumours
The expression of c-erbB-2 may be restricted to papillary and medullary carcinomas, although the published data is inconsistent.
1: using polyclonal antibody, paraffin-embedded tissue and antigen retrieval
2: using polyclonal antibody and frozen samples.
3: using monoclonal antibody, paraffin embedded tissue but no antigen retrieval.
4: using monoclonal antibodies, paraffin-embedded tissue and no antigen retrieval: immunoreactivity was purely cytoplasmic. This paper reports c-erbB-2 immunoreactivity in all types of thyroid lesions and normal parenchyma.
5: using monoclonal antibody, paraffin-embedded tissue and no antigen retrieval.
References
1Utrilla, J. C., Martin-Lacave, I., San Martin, M. V., Fernandez-Santos, J. M., Galera-Davidson, H. Expression of c-erbB-2 oncoprotein in human thyroid tumours. Histopathology 1999;34:60-65.
2 Haugen, D. R., Akslen, L. A., Varhaug, J. E., Lillehaug, J. R. Expression of c-erbB-2 protein in papillary thyroid carcinomas Br J Cancer 1992;65:832-837
3Lemoine, N. R., Wyllie, F. S., Lillehaug, J. R., Staddon, S. L., Hughes, C. M., Aasland, R., Shaw, J., Varhaug, J. E., Brown, C. L., Gullick, W. J., et al. Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia Eur J Cancer 1990;26:777-779
4Soares, P., Sambade, C., Sobrinho-Simoes, M. Expression of C-erb B2 in tumours and tumour-like lesions of the thyroid Int J Cancer 1994;56:459-461
5Roncalli, M., Springall, D. R., Varndell, I. M., Gaitonde, V. V., Hamid, Q., Ibrahim, N. B., Grimelius, L., Wilander, E., Polak, J. M., Coggi, G. Oncoprotein immunoreactivity in human endocrine tumours J Pathol 1991;163:117-127
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