Cytokeratin 1

Normal tissues

CK1

CK10

Epidermal keratinising cells

positive

positive

Hassal corpuscles of thymus

positive

positive

epithelium of gingiva and oesophagus

variably positive

liver epithelial cells

negative

pancreatic epithelial cells

negative

lung epithelial cells

negative

stomach epithelial cells

negative

colorectal epithelial cells

negative

urothelium

negative

placental amnion

positive

endothelium of some capillaries, veins and arteries

positive

always negative

fetal vasculature

negative (except placenta and umbilical cord)

vascular smooth muscle

weakly positive

gastrointestinal smooth muscle

weakly positive

first trimester myocardium

positive

adult myocardium

negative

first trimester skeletal muscle

positive

adult skeletal muscle

negative

first trimester fetal neuroepithelium

positive

adult brain

negative

Neoplasms

negative

<10%

10% to 30%

>30%

skin, basal cell carcinoma

4/5

1/5(in foci of squamous differentiation)

skin, squamous cell carcinoma

25/25

head and neck, squamous cell carcinoma

6/10

4/10 (keratinising tumours)

breast, ductal carcinoma

10/10

lung, adenocarcinoma

12/12

stomach, adenocarcinoma

10/10

colon, adenocarcinoma

29/29

hepatocellular carcinoma

3/3

bladder, transitional cell carcinoma

6/7

1/7 (with squamous differentiation)

prostatic carcinoma

17/17

uterus, endometrioid carcinoma

5/5

ovary, serous and mucinous carcinoma

20/20

negative

<10%

10% to 30%

>30%

haemangioma

2/66

13/66

12/66

39/66

lymphangioma

5/5

epithelioid haemangioendothelioma

8/8

spindle cell haemangioendothelioma

12/12

angiosarcoma

22/81

14/81

10/81

35/81

nodular fasciitis

30/30

Schwannoma

6/16

3/16

4/16

3/16

desmoid

5/5

solitary fibrous tumour

15/15

leiomyoma

10/10

leiomyosarcoma

10/10

biphasic synovial sarcoma

8/22

5/22

7/22

2/22

monophasic synovial sarcoma

41/46

4/46

1/46

epithelioid sarcoma

11/37

5/37

7/37

14/37

MPNST

16/16

rhabdomyosarcoma, embryonal and alveolar

6/6