Inhibin and calretinin in ovarian tumours

Inhibin has greater specificity but calretinin greater sensitivity for ovarian sex cord-stromal tumours.

 

inhibin

calretinin

 

  Granulosa cell

37/391
4********
3**************
2*****
1**********
0**

39/391
4*************
3************
2***************
1***
0

 

  Sertoli-Leydig

12/131
4****
3*****
2*****
1**
0*

13/131
4*******
3**
2****
1
0

 

  Sertoli cell tumour

4/41

4/41

 

  Thecoma

8/91

9/91

 

  Fibrothecoma

11/141
4*
3**
2***
1*****
0***

14/141
4****
3*
2*****
1****
0

 

  Sclerosing stromal tumour

2/21

2/21

 

  Steroid cell

3/31

3/31

 

  other stromal tumours

3/31

3/31

 

Sex cord-stromal neoplasms

80/871
4**********************
3***********************
2*******************
1********************
0*******

87/871
4************************************
3*****************
2*************************
1*********
0

 

  fibroma

3/201

19/201

 

  adenofibroma

0/91

6/91

 

  fibrosarcoma

5/81

8/81

 

Fibrous neoplasms

8/371
4*
3**
2**
1***
0*****************************

33/371
4***
3***
2***********
1****************
0****

 

  Serous carcinoma

1/111

3/111

 

  Atypical mucinous tumour

0/191

6/191

 

  Clear cell carcinoma

0/71

1/71

 

  Endometrioid carcinoma

0/151

3/151

 

  Brenner tumour

0/131

1/131

 

Epithelial tumours

1/651

14/651

 

  Dysgerminoma

0/71

0/71

 

  Yolk sac tumour

0/51

0/51

 

  Choriocarcinoma

0/11

0/11

 

  Embryonal carcinoma

0/11

0/11

 

  Immature teratoma

0/41

0/41

 

  Mixed germ cell tumour

0/41

0/41

 

Germ cell tumours

0/221

0/221

 

Mixed Mullerian tumours

0/21

0/21

 

Small cell carcinoma

0/11

0/11

 

Clear cell sarcoma

0/11

0/11

 
 

4: >75% of cells, 3: 50-75% of cells, 2: 25-50% of cells, 1: <25% of cells. Each asterisk denotes one case.

References

1Movahedi-Lankarani, S. and Kurman, R.J. Calretinin, a more sensitive but less specific marker than alpha- inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. Am J Surg Pathol 2002;26:1477-83.