p62 binds to polyubiquinated and signalling proteins such as protein kinase C and lck. It is overexpressed in some cancers.

Immunohistochemical expression


normal prostatic epithelium

negative or weak nuclear staining (9 cases)1



6/19 cytoplasmic staining, 8/19 nuclear staining1

prostatic carcinoma

41/45 cytoplasmic staining1


Diagnostic utility

Potential value in diagnosing carcinoma in prostatic biopsies.


1 Kitamura H, Torigoe T, Asanuma H, et al. Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. Histopathology 2006; 48:157-61

This page last revised 29.1.2006.

©SMUHT/PW Bishop