Tyrosinase

Immunohistochemical expression

intradermal naevus

3/33

compound naevus

4/43

junctional naevus

3/33

blue naevus

3/33

Spitz naevus

4/43

Spindle cell naevus of Reed

4/43

dysplastic naevus

4/43

negative

7% (19/266)1

<10% of tumour cells

3% (8/266)1

10% to 30% of tumour cells

7% (18/266)1

>30% of tumour cells

82% (221/226)1

negative

9/202, 30/301, 0/23

positive

<5% of cells

5/202

5-25% of cells

3/202

25-50% of cells

2/202

50-75% of cells

1/202

>75% of cells

0/202

any degree of positivity

11/202

clear cell sarcoma of tendons and aponeuroses

6/151

renal/retroperitoneal angiomyolipoma

1/121

lymphangioleiomyom(tosis)

0/61

MPNST

0/201

leiomyosarcoma

0/101

benign fibrous histiocytoma

0/201

fibrosarcoma

0/101

synovial sarcoma

0/11

angiosarcoma

0/201

poorly differentiated carcinoma

0/201

squamous cell carcinoma of head and neck

0/201

adenocarcinoma

breast, ductal

0/101

breast, lobular

0/101

lung

0/101

stomach

  

colon

  

pancreas

  

kidney

  

endometrium

  

ovary

  

ovarian & endometrial

0/201

prostate

  

total

0/50

adrenocortical carcinoma

0/121

diffuse large B cell lymphoma

0/201

anaplastic large cell lymphoma

0/41
   

Diagnostic utility

References

1Miettinen M et al. Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers. Am J Surg Pathol 2001;25:205-211.

2KJ Busam et al. Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100 and tyrosinase in desmoplastic malignant melanoma. Am J Surg Pathol 2001;25:197-204.

3Clarkson KS et al. The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB-45 and A103 (anti-melan-A). J Clin Pathol 2001;54:196-200.

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This page last revised 17.3.2001.

 

©SMUHT/PW Bishop