Antibodies are effective on paraffin-embedded tissue1.
B lymphocytes from before the pre-B stage to mature plasma cells. Since CD79a is downregulated in terminal differentiation, the continuing immunoreactivity may be due to cross-reaction with CD79b2.
97% of B cell lymphomas
rarely in T-ALL/T-LBL While the CD79a (mb-1) promoter is regulated by Pax-5, this gene is in addition at least partly regulated by PU.1, another important B-cell transcription factor. However, this transcription factor is expressed in a subset of T-acute lymphoblastic leukemias2.
The Reed-Sternberg cell of lymphocyte predominant Hodgkin's disease
some plasmacytomas
References
©SMUHT/PW Bishop