MUM1, Interferon REgulating Factor 4, IRF4

MUM1 is a lymphocyte-specific transcriptional factor, a member of the interferon regulatory factor (IRF) family, known to play a role in the regulation of gene expression in response to interferons and other cytokines. MUM1 is through to contribute to the regulation of immunoglobulin gene expression in the final step (late centrocyte) of B-cell differentiation within germinal centre light zones, initiated by centrocyte-follicular dendritic cell contact. At this stage bcl-6 is downregulated.

Immunohistochemical expression

Diagnostic utility

References

¹Petitjean, B., Jardin, F., Joly, B., Martin-Garcia, N., Tilly, H., Picquenot, J.M., Briere, J., Danel, C., Mehaut, S., Abd-Al-Samad, I., Copie-Bergman, C., Delfau-Larue, M.H. and Gaulard, P. Pyothorax-associated lymphoma: a peculiar clinicopathologic entity derived from B cells at late stage of differentiation and with occasional aberrant dual B- and T-cell phenotype. Am J Surg Pathol 2002;26:724-32.

This page last revised 27.12.2002.

©SMUHT/PW Bishop