adenocarcinoma

mesothelioma

Lafebvre 19851

17/20(pulmonary adenocarcinomas)

2/10

Szpak 19862

21/22(pulmonary adenocarcinomas: 19 cases showed staining of 10% or more of tumour cells)

9 /19(Eight cases showed staining of 1% of cells and one case showed staining of 5% of cells.)

Warnock 19889

43/43(pulmonary adenocarcinomas)

3/38

Ordonez 19893

19/23(pulmonary adenocarcinomas)

1/19

Tickman 199010 (study on cell blocks from serous fluid)

45/69(23 mammary, 16 ovarian, 10 pulmonary, 7 gastrointestinal and 13 others)

0/2

Wick 199011

43/52(peripheral pulmonary adenocarcinomas with pleural invasion)

0/51(all epithelioid mesotheliomas)

Wick4

38/43(19/23 peripheral pulmonary adenocarcinomas involving pleura, 10/10 serous surface papillary adenocarcinomas of peritoneum, 9/10 breast carcinomas metastatic to pleura. staining was predominantly membranous)

0/41(0/21 malignant epithelioid pleural mesotheliomas, 0/20 malignant epithelioid peritoneal mesotheliomas )

McCaughey 199112

not studied

0/13

Nance 199113 (study on cell blocks from serous fluid)

15/26(adenocarcinomas of various sites)

0/1

Wirth 199114

15/20(pulmonary adenocarcinomas)

24/50

Gaffey 199215

not studied

1/49(1/32 epithelioid and 0/17 biphasic)

Brown 199316

93/103(pulmonary adenocarcinomas)

0/34(all epithelioid mesotheliomas)

Moch 199317

22/24(pulmonary adenocarcinomas)

9/27(all histological types)

Dejmek 199418

15/20(adenocarcinomas of various sites, metastatic to pleura)

13/55

Bailey 199619 (study on cell blocks from serous fluid)

10/11(adenocarcinomas of various sites)

0/5

Delahaya 199720 (study on cell blocks from serous fluid)

68/88(adenocarcinomas of various sites)

1/41

Riera 199721

170/211(adenocarcinomas of various sites: 143 cases showed strong, 19 moderate and 8 weak staining. In 41 cases there was staining of >50% of cells, in 65 cases staining of 26-50% of cells and in 64 cases staining of 10-25% of cells. Staining of <10% of cells was considered as negative. Staining was generally intense but focal. A finely granular cytoplasmic staining with apical intensification was typical. Omission of heat-induced antigen retrieval decreased the number of positive adenocarcinomas without significantly increasing specificity )

2/57(all epithelioid mesotheliomas: both positive cases showed strong staining, in one case of >50% of cells, in one case of 10-25% of cells)

Wilson 199722

8/9(pulmonary and ovarian carcinomas)

1/21

Ordonez 199723

89/110(pulmonary adenocarcinomas: in approximately half the cases, the staining was of >50% of the cells. The pattern of staining was coarse and granular throughout the cytoplasm, with apical accentuation.)

3/175(in the three cases, staining was of <5% of the tumour cells)

Ordonez 199824

39/45(30 ovarian [10 primary and 20 metastatic to the peritoneum] and 15 papillary serous carcinomas of the peritoneum)

0/35(all epithelioid peritoneal mesotheliomas)

Leers19988

17/21(14 cases showing staining of >10% of cells, 3 cases showed staining of <10% of cells.)

0/20

Garcia-Prats 19987

10/18(adenocarcinomas metastatic to pleura, 10/15 pulmonary and 0/3 extra-pulmonary primaries)

0/40(26 epithelioid, 10 sarcomatoid, 4 biphasic)

Gonzalez-Lois 20015

9/12(metastatic to pleura from various sites)

4/44(3/28 epithelioid, 0/5 sarcomatoid, 0/1 mixed and 1/1 lymphohistiocytoid mesotheliomas: I kno wit does not add up!)

Comin 20016

8/23(Staining was of up to 50% of cells.)

6/42(Staining was of up to 50% of cells.)

Ordonez 200325

42/50(all primary lung adenocarcinomas: 8 case >75% of cells stained, 15 cases 50-75% of cells, 12 cases 25-50% of cells and 7 cases 1-25% of cells. Staining was course and granular throughout the cytoplasm.)

0/60(all epithelioid mesotheliomas)

Overall

81% (856/1063)

8% (79/949)