Smooth muscle actin

Immunohistochemical expression

Smooth muscle cell, including myoepithelial cells

Diagnostic utility

Identification of smooth muscle neoplasms

Identification of myoepithelial cells in breast, salivary glands and sweat glands

References

Cooke P A. filamentous cytoskeleton in vertebrate smooth muscle fibers. J Cell Biol 1976; 68:539-56

Skalli O, Ropraz P, Trzeciak A, et al. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986; 103:2787-96

Gown AM, Vogel AM, Gordon D, et al. A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol 1985; 100:807-13

©SMUHT/PW Bishop