Smooth muscle actin

Immunohistochemical expression

Smooth muscle cell, including myoepithelial cells

Diagnostic utility

Identification of smooth muscle neoplasms

Identification of myoepithelial cells in breast, salivary glands and sweat glands


Cooke P A. filamentous cytoskeleton in vertebrate smooth muscle fibers. J Cell Biol 1976; 68:539-56

Skalli O, Ropraz P, Trzeciak A, et al. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986; 103:2787-96

Gown AM, Vogel AM, Gordon D, et al. A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol 1985; 100:807-13

©SMUHT/PW Bishop