BCA-225 is a glycoprotein secreted by the T47D breast carcinoma cell line and is recognized by monoclonal antibody BRST-1. Its expression was common in adenocarcinomas of the breast, ovary, and lung but infrequent in adenocarcinomas of the gastrointestinal tract. It is less specific than either GCDFP-15 or mammaglobin for the identification of carcinomas as metastatic from the breast1.
References
1 Han JH, Kang Y, Shin HC, et al. Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma. Arch Pathol Lab Med 2003; 127:1330-4 FULL TEXT
This page last revised 28.2.2007.
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