GLUT-1

GLUT-1 is a member of the mammalian facultative glucose transporter (GLUT) family. Malignant cells commonly exhibit increased glycolytic metabolism and increased expression of glucose transport genes.

Immunohistochemical expression

 

 

Normal colonic epithelium

0/388, 0/>807, 0/119

 

Acute inflammation/regeneration without dysplasia

4/59

Inflammatory bowel disease without dysplasia

5/79

DALM

9/99

Hyperplastic polyp

0/468

Serrated adenoma

3/148

Tubular adenoma

0/77, 1/448

Tubulovillous adenoma

8/107, 0/128

Villous adenoma

4/128

Adenoma NOS

16/169

Adenoma in long standing colitis

4/59

Adenoma not contiguous with a carcinoma

0/1710

Adenoma contiguous with a carcinoma

4/1410

Colorectal carcinoma

44/538, 101/1127

   
   

Diffuse GLUT1 staining (>50% of cells) is associated with metastases and a higher mortality7,8.

 

 

Benign effusions

5/252, 1/333, 0/254

 

Malignant effusions

29/312, 19/313, 28/394

   

 

 

Benign cystic squamous lesions

0/85, 0/136

 

Metastatic squamous cell carcinomas with cystic / liquifactive degeneration

16/165 , 14/156

   

 

 

 

negative

1+

2+

3+

 
 

Reactive mesothelium

40/401

 

 

 

 

Mesothelioma

epithelioid

0/481

9/481

12/481

15/481

biphasic

epithelioid areas

1/111

6/111

3/111

1/111

sarcomatoid areas

4/111

3/111

2/111

2/111

sarcomatoid

0/11

1/11

0/11

0/11

Lung

squamous carcinoma

0/281

1/281

3/281

24/281

adenocarcinoma

2/301

11/301

6/301

11/301

             

Diagnostic utility

References

1 Kato Y, Tsuta K, Seki K, et al. Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol 2007; 20:215-20

2 Burstein DE, Reder I, Weiser K, et al. GLUT1 glucose transporter: a highly sensitive marker of malignancy in body cavity effusions. Mod Pathol 1998; 11:392-6

3 Zimmerman RL, Goonewardene S,Fogt F Glucose transporter Glut-1 is of limited value for detecting breast carcinoma in serous effusions. Mod Pathol 2001; 14:748-51 FULL TEXT

4 Afify A, Zhou H, Howell L, et al. Diagnostic utility of GLUT-1 expression in the cytologic evaluation of serous fluids. Acta Cytol 2005; 49:621-6

5 Weiner MF, Miranda RN, Bardales RH, et al. Diagnostic value of GLUT-1 immunoreactivity to distinguish benign from malignant cystic squamous lesions of the head and neck in fine-needle aspiration biopsy material. Diagn Cytopathol 2004; 31:294-9

6 Chandan VS, Faquin WC, Wilbur DC, et al. The utility of GLUT-1 immunolocalization in cell blocks: An adjunct to the fine needle aspiration diagnosis of cystic squamous lesions of the head and neck. Cancer 2006; 108:124-8 FULL TEXT

7 Haber RS, Rathan A, Weiser KR, et al. GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer 1998; 83:34-40 FULL TEXT

8 Younes M, Lechago LV,Lechago J. Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. Clin Cancer Res 1996; 2:1151-4 FULL TEXT

9 Fogt F, Wellmann A, Urbanski SJ, et al. Glut-1 expression in dysplastic and regenerative lesions of the colon. Int J Mol Med 2001; 7:615-9

10 Bakiet S, O'Sullivan J, Izzuan M et al. Glut1 staining pattern in contiguous and non-contiguous colorectal adenomas and their corresponding cancers. Abstract P32, Pathological Society July 2006.

This page last revised 20.6.2007.

©SMUHT/PW Bishop