IGH/CCND1

The IgH/CCND1 is created by a t(11;14)(q13;q32) translocation, leading to the aberrant expression of cyclin D1. It is is present in most cases of mantle cell lymphoma1.

The translocation also occurs in 15%-20% of cases of myeloma as detected by FISH, it is associated with upregulation of cyclin D1. It is likely to be associated with a serum monoclonal paraprotein of less than 10g/l, a lymphoplasmacytic morphology and a lower plasma cell labelling index. The reported prognosis in such patients has been variable, with one large study showing a better response to treatment and better survival2.

Other lymphomas including follicular lymphoma and marginal zone lymphoma are usually negative1.

Diagnostic utility

Diagnosis of mantle cell lymphoma, where FISH for the translocation is an adjunct to the demonstration of positivity for cyclin D.
- Differentiation of prolymphocytic leukaemia (negative for cyclin D1, t(11;14) and IgH/CCND1 ) from mantle cell lymphoma (positive for cyclin D1, t(11;14) and IgH/CCND1 )3.

References

1 Frater JL, Tsiftsakis EK, Hsi ED, et al. Use of novel t(11;14) and t(14;18) dual-fusion fluorescence in situ hybridization probes in the differential diagnosis of lymphomas of small lymphocytes. Diagn Mol Pathol 2001; 10:214-22

2 Fonseca R, Blood EA, Oken MM, et al. Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood 2002; 99:3735-41 FULL TEXT

3 Schlette E, Bueso-Ramos C, Giles F, et al. Mature B-cell leukemias with more than 55% prolymphocytes. A heterogeneous group that includes an unusual variant of mantle cell lymphoma. Am J Clin Pathol 2001; 115:571-81

This page last revised 17.11.2006.