OCT2

OCT2 is a transcription factor in B-lymphocytes2, that targets the octomer motifs in the immunoglobulin promotor in conjunction with co-activator BOB.1, activating immunoglobulin gene transcription. It is thought to play a role in germinal centre formation and in the differentiation of B-cells into plasma cells.

Immunohistochemical expression

Expression is nuclear.

In non-neoplastic tissue, expression is seen in a B-cell distribution.

	PU.1	BSAP	Oct-2
Nodular lymphocyte predominance Hodgkin lymphoma	15/151	15/151	15/151
Classical Hodgkin lymphoma	2/351	27/291	0/291
CLL/SLL	6/61	2/21	3/31
FL	7/71	2/21	4/41
MCL	2/31	2/21	4/61
MZL	3/31	2/21	2/21
DLBCL	11/181	9/101	15/171
TCRBCL	0/61	4/41	4/41
B-cell non-Hodgkin lymphoma	29/431	21/221	32/361
myeloma	negative1
PTCL	0/171	0/171
ALCL	0/71	0/71

1 Torlakovic, E., A. Tierens, et al. (2001). The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease. Am J Pathol 159(5): 1807-14.

2 Shah PC, Bertolino E,Singh H Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription. Embo J 1997; 16:7105-17

This page last revised 7.10.2006.