Positivity for TTF-1 in extra-pulmonary small cell carcinoma
The frequency of positivity for TTF-1 appears to vary between different anatomical sites:
|
orbit
|
0/14
|
|
sinonasal
|
0/83, 0/14, 1/1 (brain metastasis from paranasal sinus)3
|
|
thyroid
|
0/23, 1/12
|
|
salivary gland
|
0/23, 0/12, 0/14, 3/156, 1/3 (described as high-grade neuroendocrine tumours)8
|
|
thymus
|
0/34
|
|
larynx
|
1/14
|
|
gastrointestinal tract, NOS
|
2/123
|
|
oesophagus
|
5/74, 15/21 (Clone 8G7G3/1)19
|
|
stomach
|
|
|
small intestine
|
0/14, 1/2 (described as high-grade neuroendocrine tumours)8
|
|
appendix
|
0/17
|
|
colorectum
|
0/24, 1/7 (described as high-grade neuroendocrine tumours)8
|
|
liver
|
1/1 (described as high-grade neuroendocrine tumour)8, 0/112, 1/120, 0/121
|
|
pancreas
|
0/13, 1/14
|
|
renal pelvis
|
0/11, 1/14
|
|
urinary bladder
|
1/53, 2/41, 2/32, 1/34, 2/10 (described as high-grade neuroendocrine tumours)8, 2/1015, 17/44 (there was no staining for TTF-1 in the urothelial carcinoma component present in 29 of the cases)16, 11/44 (in addition, 2/2 large cell neuroendocrine carcinomas of the bladder were positive)17
|
|
prostate
|
0/33, 4/4 (using Dako antibody)1, 5/52, 1/34, 5/5 (described as high-grade neuroendocrine tumours)8, 23/44
|
|
ovary
|
|
hypercalcaemic type
|
0/7 (using monoclonal 8G7G3/1)10, 0/1525
|
|
pulmonary type
|
1/2 (using monoclonal 8G7G3/1)10, 1/1 (This small cell carcinoma arose within a microinvasive mucinous cystadenocarcionoma of the ovary. The small cell carcinoma showed moderate to strong positivity of most nuclei, the borderline epithelium moderate positivity of a few nuclei)18
|
|
|
uterine cervix
|
1/33, 1/71, 0/12, 7/164, 2/3 (described as high-grade neuroendocrine tumours of uterus: the exact site is not clear)8, 3/8 (using monoclonal 8G7G3/1)10
|
|
vagina
|
0/14, 1/311
|
|
endometrium
|
0/14
|
|
breast
|
1/12, 1/24, 1/3 (described as high-grade neuroendocrine tumours)8, 2/109, 2/214, 0/113, 0/123, 0/124
|
|
adrenal
|
1/14
|
References
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1 Agoff SN et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumours. Mod Pathol 2000;13:238-242. FULL TEXT
2 Kaufmann O & Dietel M. Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites. Histopathology 2000; 36: 415-420.
3 Ordonez NG. Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. Am J Surg Pathol 2000;24:1217-1223.
4 Cheuk W et al. Immunostaining for thyroid transcription factor-1 and cytokeratin 20 aids in the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinoma. Arch Pathol Lab Med 2001;125:228-231. (supplemented by personal communication).
5 Srodon, M. and Westra, W.H. Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases. Hum Pathol 2002;33:642-5.
6 Nagao, T., T. A. Gaffey, et al. (2004). "Small cell carcinoma of the major salivary glands: clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome." Am J Surg Pathol 28(6): 762-70.
7 Rossi, G., F. Bertolini, et al. (2004). "Primary mixed adenocarcinoma and small cell carcinoma of the appendix: a clinicopathologic, immunohistochemical, and molecular study of a hitherto unreported tumor." Am J Surg Pathol 28(9): 1233-9.
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9 Shin SJ, DeLellis RA,Rosen PP. Small cell carcinoma of the breast--additional immunohistochemical studies. Am J Surg Pathol 2001; 25:831-2
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This page last revised 23.3.2009.
©SMUHT/PW Bishop